Abstract
Purpose : We clarified the prognostic factors of primary colorectal carcinoma with peritoneal dissemination. Patients and methods : A total of 71 cases of operated primary colorectal carcinoma with peritoneal dissemination between 2002 and 2010 were reviewed. Results : Nineteen cases were categorized as P1 (for localized dissemination into adjacent peritoneum), 20 cases were P2 (for slight dissemination into remote areas of the peritoneum) and 32 cases were P3 (for marked dissemination into remote areas of the peritoneum). The 3-year overall survival rate of the patients with P1 and that of the patients with P2 were significantly better than that of P3 (50.0%, 48.2% and 9.6%, respectively P<0.01, P<0.05). Multivariate analysis showed that curativity (residual tumor classification) (HR, 3.91: P<0.05) was a significant prognostic factor affecting the overall survival rate. The 3-year overall survival rates of the patients with curativity B (Cur B: No macroscopic residual tumors) and curativity C (Cur C: with macroscopic residual tumors) were 78.4% and 15.9%, respectively (P<0.0001). In the patients with Cur B, the relapse-free survival rates and overall survival rates of the patients with P1 and those of the patients with P2 showed no significant differences (P=0.37, P=0.82). Conclusions : These findings suggest that the complete resection of primary tumor and metastatic lesions may prolong survival in patients with colorectal carcinoma accompanied by peritoneal dissemination.
