Abstract
Primary adenosquamous carcinoma of the large intestine is very rare and has been reported to be aggressive and have a poor prognosis. We report a case of adenosquamous carcinoma of the ascending colon with lymph node metastasis. A 54-year-old man was admitted to our hospital because of anemia and anal bleeding. Total colonoscopy revealed a type 2 tumor in the ascending colon, and the biopsy specimen showed moderately differentiated adenocarcinoma. Right hemicolectomy with D3 lymph node dissection was performed. The resected specimen demonstrated a type 3 tumor measuring 6.0 x 4.0cm. Microscopically, both carcinoma with squamous differentiation characterized by intracellular keratinization and adenocarcinomatous components with glandular differentiation were demonstrated. Pathologic metastasis was found in the dissected lymph nodes. The tumor was diagnosed as an adenosquamous carcinoma, A, type 3, pSS, pN2, sH0, sP0, sM0, fStage IIIb. Systemic chemotherapy with a combination of 5-fluorouracil and leucovorin was administered. The patient is alive without recurrence at 40 months after the operation.
