A Long-Term Survivor of Sigmoid Colon Adenocarcinoma with Neuroendocrine Differentiation Who Received CPT-11+CDDP Therapy Following Non-curative Resection

Abstract

A 61-year-old man was found to have a type 2 tumor of the sigmoid colon by colonoscopy and moderately differentiated adenocarcinoma was diagnosed by biopsy. Preoperative CT showed paraaortic lymph node metastasis. Radical surgery was difficult due to cirrhosis, so he underwent a Hartmann operation with D2 lymph node dissection. The operation was not curative due to paraaortic lymph node metastasis. The pathological diagnosis was adenocarcinoma with about 20% neuroendocrine differentiation in the primary tumor and about 30% neuroendocrine differentiation in the metastatic lymph nodes. Postoperative chemotherapy included CPT-11 and CDDP based on the chemotherapy regimen for small cell lung carcinoma. After 2 cycles, paraaortic lymph nodes significantly decreased in size, and 4 additional cycles were given. On follow-up 61 months postoperatively and 54 months after chemotherapy the patients was disease-free.