Abstract
We present two cases of gastric adenocarcinoma following complete remission of gastric diffuse large B cell lymphoma (DLBCL) after stomach-conserving treatment. The patients were a 61-year-old man and a 67-year-old woman. Each patient had been given a diagnosis of stage I gastric DLBCL. One patient had undergone chemotherapy, and the other had undergone chemoradiotherapy. After achieving complete remission of DLBCL, upper endoscopic studies during follow-up showed gastric adenocarcinoma in both cases. Both patients underwent total gastrectomy and lymph node dissection for the treatment of gastric adenocarcinoma, and histological examination of the resected specimen revealed stage IA gastric cancer with no residual gastric lymphoma. Patients who undergo stomach-conserving treatment for gastric DLBCL have favorable prognoses. However, recently, incidences of secondary malignancy following complete remission of lymphoma have been reported, suggesting that careful follow-up is important in such cases.
