Abstract
A 79-year-old woman with jaundice was referred to our hospital for further examination and possible surgery. Abdominal ultrasonography, computed tomography, and endoscopic retrograde cholangiopancreatography showed an extrahepatic bile duct cancer with a portal vein tumor thrombus. Subtotal stomach-preserving pancreaticoduodenectomy with the extraction of a portal vein tumor thrombus by portal vein resection and reconstruction was performed. Histopathologically, the bile duct tumor consisted of adenocarcinoma and squamous cell carcinoma components, indicating adenosquamous carcinoma. Moreover, carcinoma in situ was found in the pancreas head. Therefore, the final diagnosis was synchronous double cancer of the bile duct and pancreas. The patient had multiple liver metastases and lymph node metastases two months after surgery, and died four months after surgery.