Prognostic Factors for Patients with Severe Peritonitis Treated by Polymyxin-direct Hemoperfusion after Emergency Digestive Surgery

Abstract

Purpose: We investigated prognostic factors for patients with severe peritonitis who had undergone emergency digestive surgery and had been treated with polymyxin B immobilized fiber column direct hemoperfusion (PMX-DHP). Methods: Sixty-eight patients that had PMX-DHP over the past 8 years were enrolled in this study. The patients were divided into two groups: the survival group and the non-survival group. The patients’ backgrounds and other parameters were compared between the two groups and analyzed by univariate and multivariate analysis. Results: The univariate analysis revealed that age, catecholamine index (CAI), Cr, platelet counts (Plt), Glasgow Coma Scale (GCS), acidosis, Acute Physiology and Chronic Health Evaluation II (APACHE II) score, and Sequential Organ Failure Assessment (SOFA) score were important factors affecting prognosis. The multivariate analysis found that the SOFA score was the only isolated risk factor. Conclusion: There was a high mortality rate for patients with severe diffuse peritonitis, particularly those with high SOFA scores; the effectiveness of PMX-DHP was limited in these patients.