Two Cases of Duodenal Varices during the Course of Oxaliplatin-Based Chemotherapy for Colorectal Cancer

Abstract

Hepatic sinusoidal injury occasionally arises after oxaliplatin-based chemotherapy. Although esophagogastric varices associated with subsequent portal hypertension occur in some cases, there have been few reports of ectopic varices in Japan. In this paper, we present 2 cases of duodenal varices during the course of oxaliplatin-based chemotherapy for colorectal cancer. Interventional radiology for duodenal varices was successfully applied in both cases to prevent bleeding from varices. Oxaliplatin is one of the key drugs in the treatment of unresectable metastatic colorectal cancer, but it is necessary to pay attention to the onset of complications due to portal hypertension. In addition, our cases implied that interventional radiology is considered to be a promising treatment for varices that occurred concurrently during oxaliplatin-based chemotherapy.