2020 Volume 53 Issue 11 Pages 892-900
Recently, immunohistochemical staining for ΔNp63 (p40) has been widely used to diagnose squamous cell carcinoma. While there have been many reports that have evaluated the usefulness of ΔNp63 (p40) for diagnosing squamous cell carcinoma of the lung to date, the number of reports of the diagnostic usefulness of ΔNp63 (p40) for other carcinomas has increased. We report three cases of adenosquamous cell carcinoma of the pancreas and evaluate the usefulness of ΔNp63 (p40) in diagnosing them. Case 1: A 71-year-old man underwent distal pancreatectomy for carcinoma of the pancreatic body. Case 2: A 81-year-old woman underwent pylorus preserving pancreaticoduodenectomy for carcinoma of the pancreatic head. Case 3: A 55-year-old man underwent distal pancreatectomy for carcinoma of the pancreatic tail. All cases were histologically diagnosed as adenosquamous carcinoma of the pancreas. The squamous cell carcinoma components of these cases were positive for ΔNp63. ΔNp63 allowed us to easily recognize squamous cell carcinoma components in areas in which it was difficult to discriminate whether squamous carcinoma components were included due to unclear cell differentiation. It is conceivable that immunohistochemistry for ΔNp63 could be useful in diagnosing adenosquamous carcinoma of the pancreas.
