2024 Volume 57 Issue 5 Pages 265-273
A female patient underwent enucleation of a solid-pseudopapillary neoplasm (SPN) of the pancreatic head at 12 years of age, followed by a total of four surgeries for local recurrence, duodenal metastasis, and liver metastasis. At 45 years of age, a hilar mass and two hepatic masses were found, and a fifth resection was performed with diagnosis of local recurrence and liver metastasis. She has been free of recurrence for 3 years since the last surgery. Pancreatic SPN is generally considered to be a low-grade tumor with low metastatic potential and low recurrence rates, and cases of patients who undergo four surgeries for recurrence and survive for more than 30 years are rare. Several factors have been investigated to identify highly malignant SPN, but no conclusive evidence has been established. Long-term postoperative follow-up appears to be required throughout life.
