2025 Volume 58 Issue 3 Pages 177-184
Adenosquamous carcinoma, in which adenocarcinoma and squamous cell carcinoma are simultaneously present in the same lesion, is rare among gallbladder cancers and is considered to have a poor prognosis. In this study, we retrospectively reviewed the cases of 10 patients who underwent surgical resection for adenosquamous carcinoma located in the gallbladder from 2008 to 2022. The most common surgical procedure was gallbladder bed resection (8 cases), and concomitant resection of other organs was performed in 4 cases. Eight cases were T3/4, 6 had positive lymph nodes metastasis, and 8 achieved R0 resection. Three cases had postoperative complications of Clavien-Dindo grade 3 or higher. The median overall survival after resection was 6.7 months, and 3 of the 4 patients who were able to receive adjuvant therapy survived for more than two years. The prognosis tended to be poor in cases with postoperative complications or lymph node metastasis. Adenosquamous carcinoma of the gallbladder is a tumor with a poor prognosis even if radical resection can be performed because the disease is often advanced when detected. Introduction of multidisciplinary treatment is likely to improve the oncologic outcome.
