Abstract
We made a metastatic liver tumor model by injecting VX2 tumor cells into the portal vein of a rabbit. We then examined the suppressive effect of Adriamycin against liver metastasis, when administered through the portal vein in an adequate dose determined by a pharmacokinetic study. The minimum effective ADR concentration was determined in a sensitivity test using cultured VX2 tumor cells. And the pharmacokinetics of portal and systemic administration was analyzed with doses of 0.2, 0.4 and 0.8mg/kg of body weight. The liver extraction ratio was higher with the smaller doses, but satisfactory liver concentration over the minimum effective concentration was achieved with a dose of 0.4mg/kg. Complete suppression of liver metastasis was achieved by administering ADR 7 times at a dose of 0.4mg/kg.
