A Case Report of Middle-aged Women with Solid and Cystic Tumor of the Pancreas

Abstract

Solid and cystic tumor of the pancreas is a rare low-grade malignant tumor occurring chiefly in young women. We report the case of a 49-year-old woman who received a pancreatoduodenectomy for a tumor in the uncal region of the pancreas. The tumor mass was 7×5×5 cm in diameter and well encapsulated. The cut surface showed extensive necrosis and hemorrhage except for some solid areas along the inside of the capsule. Histologically, sheets of tumor cells surrounding thin-walled vessels containing erythrocytes were predominant with some oval cells arranged about a fibrovascular stalk or a small blood vessel and focal invasions of the fibrous capsule. In addition, most tumor cells negative for Grimelius' stain were immunohistochemically positive for α₁-antitrypsin and showed no immunoreactivity with insulin, glucagon, estrogen receptor or progesterone receptor. These findings suggest that the tumor cells were capable of differentiation to acinar cells and had malignant potentiality.