Analysis on Hepatic Recurrence in Colorectal Cancer with Resected Hepatic Metastases

Abstract

Patterns of recurrence were examined in 40 patients who had resected of hepatic metastases from colorectal cancer. Twenty-five patients (62.5%) of these patients have had recurrence and 42.5% percent have had recurrence in the liver after hepatectomy. The hepatic recurrence rates did not correlate with the lobar distribution of metastases, number of lesions or surgical methods. As the size of the largest, tumors of over 5 cm were at an increases risk of having a recurrence in the residual liver. Positive pathologic margins were related to hepatic recurrence. The hepatic recurrence rate of aneuploid tumor was significantly higher than rate for diploid tumors. Eight patients received chemotherapy intrahepatically via a hepatic arterial catheter in selecting drugs by SDI test. The hepatic recurrence rate of patients with hepatic infusion chemotherapy was 25 percent, which was lower than the rate of 46.9 percent for ones without hepatic chemotherapy. The use of the SDI test will aid in selecting drugs for the prevention of hepatic recurrence after hepatectomy.