大腸癌の深部浸潤に伴う核DNA量の変化-そのheterogeneityについて

今田 敏夫; 須田 嵩; 鬼頭 文彦; 岡田 賢三; 岡田 卓子; 福沢 邦康; 森脇 義弘; 秋山 浩利; 竹村 浩; 松本 昭彦

doi:10.5833/jjgs.25.2760

Heterogeneity of DNA Content According to the Depth of Invasion in Colorectal Cancer

Toshio Imada, Takashi Suda, Fumihiko Kito, Kenzo Okada, Takako Okada, Kuniyasu Fukuzawa, Yoshihiro Moriwaki, Hirotoshi Akiyama, Hiroshi Takemura, Akihiko Matsumoto

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Toshio Imada
Department of Surgery, Saiseikai Yokohamashi Nambu Hospital
Takashi Suda
Department of Surgery, Saiseikai Yokohamashi Nambu Hospital
Fumihiko Kito
Department of Surgery, Saiseikai Yokohamashi Nambu Hospital
Kenzo Okada
Department of Surgery, Saiseikai Yokohamashi Nambu Hospital
Takako Okada
Department of Surgery, Saiseikai Yokohamashi Nambu Hospital
Kuniyasu Fukuzawa
Department of Surgery, Saiseikai Yokohamashi Nambu Hospital
Yoshihiro Moriwaki
Department of Surgery, Saiseikai Yokohamashi Nambu Hospital
Hirotoshi Akiyama
Department of Surgery, Saiseikai Yokohamashi Nambu Hospital
Hiroshi Takemura
Department of Surgery, Saiseikai Yokohamashi Nambu Hospital
Akihiko Matsumoto
First Department of Surgery, Yokohama City University, School of Medicine

Keywords: DNA content of colorectal carcinoma, heterogeneity, flow cytometry

JOURNAL FREE ACCESS

1992 Volume 25 Issue 11 Pages 2760-2764

DOI https://doi.org/10.5833/jjgs.25.2760

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Abstract

Thirty-one cases of colorectal carcinoma were investigated for intratumor heterogeneity in DNA ploidy, DNA index, and S-phase fraction. DNA content of samples from the superficial layer and the deep layer in the same tumor was determined by flow cytometry. Heterogeneity of the DNA ploidy patternwas observed in 3 cases (9.7%). The DNA index was 2.18 and 2.11 and the S-phase fraction was 30.4% and 28.6% inthe superficial and deep layers, respectively. These data indicate a low degree of intratumoral heterogeneity of DNA content according to the depth of invasion in colorectal carcinoma.

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