Abstract
Flow cytometric (FCM) DNA studies were performd on cell suspensions of biopsy specimens from gastric mucosa in 73 patients with gastric cancer. DNA aneuploidy was detected in 49 tumors (67.1%), that is, in5l.7% (15/29) of early gastric cancers and77.3% (34/44) of advanced gastric cancers. The DNA index (DI) ranged from 1.0 to 2.8. A significant correlation was found between the DI of biopsy materials and that of surgically obtained ones (r=0.9426). Serosal invasion, lymph node metastasis, lymphatic invasion, and vascular invasion were significantly higher in aneuploidy than in diploidy (p<0.05). The prevalence of aneuploidy in endoscopically obtained specimens may provide additional prognostic information and information on biologic variables.
