Hepatic Resection in a Patient with Hemophilia A-A Protocol for Supplementation of Factor VIII Concentrate

Abstract

We performed a successful right lobectomy of the liver in a hemophilia A patient with hepatocellular carcinoma under supplementation of factor VIII concentrate. We administered 2500 units of factor VIII concentrate one hour prior to surgery. The intraoperative course was uneventful except for oozing from the abdominal wall near the end of the operation. This was controlled by an additiona12500 units of factor VIII concentrate. Since blood coagulation factorts including factor VIII are consumed more extensively in major hepatic resection than other kinds of abdominal surgery, supplementation of a lager amount of factor VIII concentrate may be necessary in the intra-and postoperative management of hepatic surgery in hemophilia patients.