Abstract
The expression of c-erbB-2 protein was examined immunohistochemically in a total of 75 freshly frozen specimens of colorectal cancer, and correlations between its expression and clinicopathological variables were analyzed. Seventy-five cases were scored by assessing the intensity of staining (strongly positive, weakely positive and negative). The incidence of strongly positive staining of c-erbB-2 protein among the 75 cases was 29.3%, and strongly positive staining was significantly correlated with lymph node metastasis, lymphatic or vascular invasion, liver or lung metastasis and Dukes' stage. These results suggest that the expression of c-erbB-2 protein may serve as a useful biological marker in colorectal cancer.
