Pancreatic Adenosquamous Carcinoma with Different Modes of Invasion, Squamous Cell Carcinoma from Adenocarcinoma

Abstract

A 45-year-old man was admitted to our hospital because of melena and severe anemia. Endoscopic findings showed gastric varices. Magnetic resonance imaging (MRI) clearly documented a pancreatic tail tumor. At laparotomy, a tumor, 3.0cm in diameter, was located in the pancreatic tail, infiltrating and completely obstructing the splenic vein at the splenic hilus. Distal pancreatectomy associated with splenectomy and lymph node dissection was carried out. The tumor was histologically adenosquamous cell carcinoma of the pancreas. The different carcinoma cells of adenocarcinoma and squamous cell carcinoma showed different modes of infiltration. The adenocarcinoma invaded the perineural space and the squamous cell carcinoma extended the splenic vein and made the tumor thrombus.