Abstract
Cell proliferation kinetics of the non-neoplastic mucosa and carcinoma cells in 19 cases of resected remnant stomach were investigated by examining the number of nucleolar organizer region associated proteins after staining by silver colloid (AgNOR). The mean numbers of AgNOR in the nucleus were 1.38±0.14 in the mucosa at the proximal margin, 1.82±0.24 in the anastomotic region (p<0.001). Hyperplasia in the foveolar gland, the gland with invasion into the submucosa, and the gland with cystic dilatation were frequently recognized in the mucosa in the anastomotic region after Billroth II reconstruction. The mean numbers of AgNOR were 2.17±0.13 in the region of hyperplasia of the foveolar gland, 2.03±0.04 in the gland invading the submucosa, and 1.94±0.14 in the gland with cystic dilatation. All three of these mean numbers of AgNOR were significantly higher than in normal mucosa. These results suggested that the mucosa in the region of anastomosis promoted these activities probably in part due to the incidence there of duodenal reflux.
