Experimental Studies of the Effects of Prostaglandin E₁ Administration to Rats with Liver Dysfunction Induced by Endotoxin

Abstract

We investigated the effect of prostaglandin E₁ (PGE₁) on rats with liver dysfunction induced by endotoxin. The dose of PGE₁ did not exceed 0.1μg/kg/min, which did not affect the circulation adversely. The rats were divided into three groups as follows: the Ex-group was given endotoxin alone; the Ex+0.02 PGE₁-group was given endotoxin and 0.02μg of PGE₁; the Ex+0.1 PGE₁-group was given endotoxin and 0.1 μg of PGE₁. We compared the liver function (T-Bil, GPT, LDH, ALP), arterial blood pressure (BP) and liver tissue blood flow (TBF) in these groups. In the Ex+PGE₁-group liver function was exacerbated though in the Ex+0.02 PGE₁-group T-Bil was improved. BP and TBF showed little difference among these groups. These results suggested that both doses of PGE, had an adverse effect on liver dysfunction induced by endotoxin.