1996 Volume 29 Issue 8 Pages 1721-1728
This experiment was designed to evaluate the role of reflux of gastric juice, bile or pancreatic juice in the genesis of reflux exophagitis. Barrett's esophagus and/or esophagel adenocarcinoma. Mongrel dogs were divided into four groups: reflux of gastric juice (group A, n=12), reflux of bile (group B, n=14), reflux of pancreatic juice (group C, n=12) and a control group with only laparotomy (group D, n=3). These dogs were observed over six years. Barrett's esophagus was seen after a mean of 38 months in eight of twelve dogs, dysplasia in three dogs after a mean of 52 months and esophageal adenocarcinoma in one dog after 72 months in group A. In four dogs, dysplasia after a mean of 41 months, and in one dog, esphageal adenocarcinoma after 60 months were observed in group B. Barrett's esophagus and adenocarcinoma were not seen in group C. These results suggested that Barrett's esophagus and/or adenocarcinoma may occur from reflux of not only gastric juice but also bile, but may not from reflux of pancreatic juice.
