Extent of Suitable Resection for Bile Duct Carcinoma-From the Mode of Spreading and Biological Behavior

Abstract

Macroscopically, hepatic bile duct carcinoma was divided into 3 types, papillary (P), nodular (N) and diffuse (D). P-type expressed cadherin and catenin mores trongly than N-and D-types. Expression of both cadherin and catenin was stronger in pap and tubl than tub 2.The nuclear area of the cancercell, which correlated with both the labeling index of Ki-67 and aberrant accumulation of p53, was significantly larger in the subserosal layer than in the mucosal layer. These findings may explain the differences in biological behavior between P-and N, D-types. P-type grows with in the mucosal layer, while N-and D-types are more in vasive, extending into the subserosal layer. Inreality, thepoorforN-, D-type of hepatic bile duct carcinoma after surgery is clinically observed. Therefore, for the treatment of N, D-type bile duct carcinoma, more extensive surgical intervention including resection of the liver and vessels is required.