Retrospective Studies on Multiple Modalities of Therapy for Advanced Gastric Cancer with Peritoneal Metastasis from the Aspect of Patient Prognosis and Outpatient Interval

Abstract

We investigated whether multiple modalities of therapy for advanced gastric cancer with peritonealmetastasis could lengthen the patient's survival time and outpatient interval. Between 1984 and 1995, 108patients undergoing surgery for gastric cancer at our department were found to have peritoneal metastasis. With generalized Wilcoxon test, gastrectomy, postoperative chemotherapy (POC), performance status (PS), age, operative peritoneal chemotherapy (OC), nodal status (N) and peritoneal status (P) showed significant differences. Multivariate analysis with Cox's proportional hazard model showed gastrectomy, POC, P, OC and sex are significantly potent prognostic factors. In the aspect of home care duration, age, PS, complications, preoperative chemotherapy, N, gastrectomy and OC showed significant differences. These results suggests that gastrectomy and chemotherapy in the perioperative period might be useful for gastric cancer with peritoneal metastasis.