Abstract
In 360 resected cases of gastric cancer, the clinical significance of serum immunosuppresive acidic protein (IAP) values for gastric cancer was evaluated in comparison with that of serum carcinoembryonic antigen (CEA) values.(1) The positive rates of IAP and CEA were 18.6% and 14.7%, respectively. In 174 cases without early gastric cancer, those were 30.5% and 19.0%, respectively.(2) Both the serum IAP and CEA values showed a correlation with histological staging, lymphatic invasion, lymphnodal metastasis and liver metastasis.(3) The depth of invasion and venous invasion showed a significant correlation with serum IAP values, but not with serum CEA values.(4) Serum IAP values were positive in eight of nine values, but not with serum CEA values.(5) Serum IAP values were positive in eight of nine cases with liver metastasis, and that sensitivity and negative predictive value of IAP were very high, 88.9% and 99.7%, respectively. These results indicate that the serum IAP values is a useful tumor marker more than the seurm CEA values for preoperative evaluation of the cancer stage of gastric cancer.
