肝硬変例におけるトリメタジオン負荷試験とChild-Pugh scoreとの対比について

松田 充宏; 石川 詔雄; 辻 勝久; 長田 明; 山本 祐二; 大塚 雅昭; 轟 健; 深尾 立; 田中 栄之介

doi:10.5833/jjgs.31.36

Comparison of Trimethadione Tolerance Test and Child-Pugh Score in Patients with Liver Cirrhosis

Mitsuhiro Matsuda, Akio Ishikawa, Katsuhisa Tsuji, Akira Osada, Yuji Yamamoto, Masaaki Ohtsuka, Takeshi Todoroki, Katashi Fukao, Einosuke Tanaka

Author information

Mitsuhiro Matsuda
Department of Surgery, Institute of Clinical Medicine, University of Tsukuba
Akio Ishikawa
Department of Surgery, Institute of Clinical Medicine, University of Tsukuba
Katsuhisa Tsuji
Department of Surgery, Institute of Clinical Medicine, University of Tsukuba
Akira Osada
Department of Surgery, Institute of Clinical Medicine, University of Tsukuba
Yuji Yamamoto
Department of Surgery, Institute of Clinical Medicine, University of Tsukuba
Masaaki Ohtsuka
Department of Surgery, Institute of Clinical Medicine, University of Tsukuba
Takeshi Todoroki
Department of Surgery, Institute of Clinical Medicine, University of Tsukuba
Katashi Fukao
Department of Surgery, Institute of Clinical Medicine, University of Tsukuba
Einosuke Tanaka
Institute of Community Medicine, University of Tsukuba

Keywords: trimethadione tolerance test, cytochrome P450, liver function test, Child-Pugh score, liver cirrhosis

JOURNAL FREE ACCESS

1998 Volume 31 Issue 1 Pages 36-39

DOI https://doi.org/10.5833/jjgs.31.36

Details

Abstract

In this study, we examined the relationship between the trimethadione (TMO) tolerance test and the Child-Pugh score in patients with liver cirrhosis to determine if there is an advantage of the TMO tolerance test. The TMO tolerance test is based on the serum dimethadione (DMO)/TMO ratio (DMO is the only metabolite of TMO) 4 hours after oral administration of TMO. The DMO/TMO ratios were 0.33±0.07 in group A of the Child-Pough score, 0.26±0.10 in group B and 0.11±0.06 in group C. These defferences reached statistical significance (p<0.005). There was a significant correlation (r=- 0.186, p<0.0001) between the serum DMO/TMO ratio and the Pugh score. These data show that the TMO tolerance test is as useful for assessing the severity of liver cirrhosis as the Child-Pugh score.

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