Abstract
A selective thromboxan A2 (TXA2) synthetic enzyme inhibitor, CV-4151, was injected into an bile-induced acute pancreatitis model in dogs. Mongreal adult dogs were divided into 4 groups (group 1, untreated control: group 2, one-shot intravenous injection: group 3, continuous intravenous injection: group 4, continuous intraarterial injection) and the relative efficacy of each method of administration and the effects of CV-4151 were cmpared among the groups. Pancreatic tissue was harvested before and 1 and 3 hours after the induction of pancreatitis, and the levels of phospholipase A2 (PLA2), thromboxan B2 (TXB2), and 6-keto-PGF1α in the tissue were measured. The survival rate for eachgroup was determined. The results showed that PLA2 and TXB2 were suppressed significantly after 1 and 3hours in group 4 and 6-keto-PGF1α was suppressed significantly after 3 hours in group 4. Group 4 showed the highest survival rate among four groups. These findings indicate that a therapeutic effects similar to that seen in groups 2 and 3 can be expected from the continuous intraarterial injection of CV-4151. Furthermore, this method also yielded the highest survival rate.
