Abstract
To determine the clinical role of abnormality in the P53-dependent apoptosis pathway, immunohistochemical analysis was performed in patients with gastric carcinomas. The subjects of this study were 30 patients who were treated by preoperative chemotherapy for gastric carcinomas. 17 patients were medicated with 5'DFUR (p.o. group) and 13 patients were injected with CDDP (i.v. group). We choiced p53, Bax and Bc1-2 in the biopsy materials before chemotherapy for parameters. And we choiced histological evaluation, Ki-67 labeling index after chemotherapy and positive rate of Lewis Y antigen after chemotherapy for grades of chemotherapeutic effect. The positive rate of Lewis Y antigen after chemotherapy correlated with histological evaluation of chemotherapy both in p.o. group and in i.v. group (p<0.05). At i.v. group, the p53-positive group showed poor responses to chemotherapy both in histological evaluation and in positive rate of Lewis Y antigen after chemotherapy (p<0.05). At p.o. group, the P53-positive group showed poor response to chemotherapy in histological evaluation (p<0.05). These results indicate that, in gastric carcinomas, expressionof P53 in the biopsy materials before chemotherapy predicts a poor response to preoperative chemotherapy.
