Abstract
To evaluate the effects of preoperative chemotherapy for advanced gastric cancer, we histopathological effects, the changes in the nuclear area (NA) and the coefficient of variation (NACV) of residual cancer cells. Thirty patients were treated by continuous i. v.5FU injection (300mg/m2/day) until the day before the operation (FU group). Forty-twopatients were treated with C. I.V 5FU by i. v. injection of low a dose of CDDP (15mg/m2/day) on day 1 and 2 (CF group). These compared with two groups were given a no treatment group (20cases). According to the Japanese classification of gastric carcinoma, the histological effects were as follow: FU group (Gr0, 9; Gr1a, 13; Gr1b, 5 and Gr2, 3.) and CF group (Gr0, 10; Gr1a, 21; Gr 1b, 5; Gr2, 5; and Gr3, 1.). These were no nignificant histological differences between the FU and CF groups. The values of NA were as follows: control (47. 6μm2), FU group (Gr0, 50. 5; Gr1a, 58. 8; Gr1b, 65. 2; and Gr2, 72. 6.) and CF group (Gr0, 70. 2; Gr1a, 64. 2; Gr1b, 49. 8; and Gr2, 33. 8.). The values of NACV were as follows: control (27. 0%), FU group (Gr0, 27. 9; Gr1a, 30. 7; Gr1b, 38. 4; and Gr2, 30. 5.) and CF group (Gr 0, 32. 1; Gr1a, 34. 6; Gr1b, 50. 8; and Gr2, 50. 3.). Low a dose CDDP causes a decrease in NA and an increase in NACV in patients with a high-grade response to preoperative 5FU chemotherapy. These findings suggest that a valuation of NA and NACV in useful for the prediction of chemosensitivity and that low a dose CDDP isan important factor as not only an effector but also a modulator in biochemicall modulation of 5FU chemotherapy
