Abstract
This study was conducted to evaluate the preventive effect of chinese medicine of Dai-saiko-to (CM-8), Sho-saiko-to (CM-9) and Inchin-go-rei-san (CM-117) on gallstone formation after truncal vagotomy in the hamster. Gallstone formation was observed in 100% of the control hamsters and 50% of those treated with CM-8, 55.6% with CM-9 and 62.5% with CM-117. Total bile acid concentration in the gallbladder bile was lower in the CM-8 group and higher in the CM-9 and TJ-117 groups. In the molecular forms of bile acids, the ratios of cholic acid to chenodeoxycholic acid (CA/CDCA) and secondary bile acid to primary bile acid (S/P) were improved in the CM-9 and CM-117 groups. However, it was not improved in the CM-8 group. The preventive effect of the extracts on gallbladder stone formation was closely related with biliary constituents and the melecular forms of bile acids in the CM-9 and CM-117 groups. In the CM-8 group, the preventive effect might be dependent upon other factors.
