2002 Volume 35 Issue 1 Pages 116-119
From 1996 to 2000, 105 patients with hepatocellular carcinoma (HCC) underwent inital surgical treatment (hepatectomy in 62 and ablation in 43) at our institute. Twelve of the 105 suffered extrahepatic metastasis. Nine of the 12 had intrahepatic metastasis, and 6 were controlled by various treatment to liver (TAE, CAI, MCT, RFA and resection). Metastatic sites of the 12 with multiple organ recurrence were lung (7), peritoneum (5), lymph node (4), adrenal gland (3), bone (1), brain (1), and stomach (1). These extrahepatic lesions were treated by resection in 15, systemic chemotherapy in 6, and radiation in 3 (overlapping occurred). The 1-year survival of the 12 was 67% and 3-year survival was 39%. The 3-year survival of those with resected extrahepatic metastasis (69%, n=7) was significantly better than that of unresected (0%, n=5, p=0.0045). In those with resected extrahepatic metastasis, intrahepatic recurrence was controlled of all. These results suggest that extrahepatic HCC metastasis should be resected if the lesion is completely resectable and intrahepatic recurrence is controlled.
