Abstract
Aim: We clarified whether the maximal horizontal size of subserosal invasion influences prognosis. Materials and Methods: Of 69 patients with gallbladder cancer who underwent surgical resection between 1975 and 2002, 28 had T2 gallbladder cancer (depth of invasion ss, including hinfα and excluding positive binf). We stud- ied the relationship between pathological factors of resected specimens and prognosis. Results: Subjects were 28 patients- 6 men and 22 women aged 45 to 82 years (mean 67.6 years). Five-year postoperative sur- vival of the 28 was 48%. Presence of lymph node metastasis, positive em, and positive bm were significant fac- tors related to poor prognosis. Patients with INF α showed relatively good prognosis, as did those with subse- rosal invasion less than 10mm in maximal horizontal size, whose prognosis was significant good. Discussion: Results suggested that the factor showing good prognosis was a maximal horizontal size of less than 10mm in- vading the subserosal layer. Preoperative diagnosis of subserosal invasion is reported to be possible to some extent by EUS, so this factor will provide useful preoperative information.
