Abstract
A 62-year-old woman hospitalized for fever and systemic malaise and referred for a pancreatic tumorous le-sion detected by computed tomography (CT) and abdominal ultrasonography (US) was found in preoperative laboratory data to have leukocytosis (15, 700/mm3) and high serum CA19-9 (1, 342U/ml). CT showed an un-evenly enhanced mass in the pancreatic tail that invaded to the spleen. US showed a heterogenous hypoechoic mass in the pancreatic tail. Following distal pancreatectomy, pathological examination showed anaplastic duc-tal carcinoma, and immunohistochemical study showed positive staining for G-CSF in the tumor cell, leading to a diagnosis of G-CSF-producing tumor. After the surgery, the leukocyte count continued to increase and the patient died on postoperative day 38 due to cancer cachexia and disseminated intravascular coagulation. G-CSF-producing pancreatic cancer is very rare, with 8 cases, including ours, having been reported.
