Abstract
A 76-year-old man admitted for tarry stool and suspected of duodenal poorly differentiated adenocarcinoma infiberscopic biopsy underwent pylorus-preserving pancreaticoduodenectomy in which surgical findingsshowed a duodenal tumor, 5 jejunal tumors, and mesenteric lymph node metastasis. Histopathological findingsof positive immunohistochemical staining for KIT showed these tumors to be gastrointestinal stromal tumors (GIST). One month postoperatively, he suffered cramps and was diagnosed with multiple brain metastases.Although treated with whole-brain radiation and medicated with imatinib mesylate, he died 6 months aftersurgery. This extremely rare case involved GIST accompanied by lymph node and brain metastasis, suggestingthe multiple modality of GIST.
