2005 Volume 38 Issue 8 Pages 1301-1305
We report a 67-year-old man with alpha-fetoprotein (AFP)-producing gastric cancer and synchronous liver metastasis with a portal tumor thrombus. After being followed up elsewhere for hepatitis C virus infection, he was admitted in August 1999 for a liver tumor found due to high serum AFP. Abdominal CT showed a 7.5cm - diameter tumor developing into a portal branch in the right hepatic lobe. Gastrointestinal fiberscopy showed a type 2 tumor in the remnant stomach, histologically diagnosed as poorly differentiated adenocarcinoma. We diagnosed lesions as hepatocellular carcinoma and gastric cancer in the remnant stomach. Three weeks after percutaneous transhepatic portal embolization, we conducted extended right hepatic lobectomy and partial gastric resection. Since both hepatic and gastric tumors were positive for AFP immunohistochemical staining, we diagnosed him histologically as having AFP-producing gastric cancer with liver metastasis. He underwent adjuvant chemotherapy with 5-FU and CDDP and is doing well without recurrence more than 5 years after surgery.
