Clinicopathological Study on the Prognostic Factors of stage IV Colorectal Cancer

Abstract

Purpose: We clarified the prognostic factors of stage IV colorectal cancer. Materials and Methods: We analyzed 161cases of stage IV colorectal cancer clinicopathologically to determine prognostic factors. Results: We found 37cases (23.0%) with curability (cur) B, 110 (68.3%) with cur C, and 14 (8.7%) with curability unknown. For the number of non-curative factors, 111cases (68.9%) had a single factor and 50 (31.1%) multiple factors. The most frequent factor among single non-curative cases was liver metastasis (57.7%), followed by peritoneal metastasis (18.9%). Multivariate analysis indicated that curability, differentiation, tumor depth, the number of non-curative factors, and lymphatic invasion are independent prognostic factors. All those surviving over 5years had a single non-curative factor with well-to moderately-differentiated adenocarcinoma, and underwent cur Bresection. Conclusions: Extended resection for metastatic lesions may prolong survival in stage IV colorectal cancer when a) a single non-curative factor exists and b) adenocarcinoma is well-to moderately-differentiated.