Abstract
We report a case of a fairly rare mesenchymal gastrointestinal mesenchymal tumor (GIMT) of the colon. A 46 year-old man with a history of sudden epigastric pain was found in Computed Tomography (CT) to have 6-cm diameter mass in the transverse colon complicated by peritoneal free air and massive fluid accumulation. Emergency surgery showed the mass to be a perforated submucosal tumor leading to peritonitis. Histologically, the resected tumor showed increased spindle cells with neutrophilic proliferation at the perforation. Immunofluorescence microscopy showed positive findings for vimentin but negative for c-kit, CD34, S-100, and SMA all compatible with GIMT.