When rabbits and rats were fed the diet containing excessive salt in proportion to 30gr a day per adult human for two years, cholesterol in blood were increased and P.S.P. was delayed. In the media of the aorta edematous swelling was observed and elastic fibre was greatly swollen and degenerated. In the kidney glomeruli were damaged and endothelial cells of Henle's tubules were degenerated and frayed. These changes were not found in the animals fed a calcium diet with excessive salt together.
The vessels and the kidney of the animals given Saké at the rate of 360cc a day per adult human for two years showed similar changes to those caused by excessive salt, though these were usually less severs. In the liver cells, however, fat degeneration was observed in every instance.