Clinico-chemical Studies on Chronic Cadmium Poisoning

(Part 6) Renal clearances of amino acids

Abstract

Endogenous renal transport of free amino acids was determined in six suspected itai-itai patients (female) (group A: severe cadmium poisoning), thirteen women with renal damage from cadmium (B) and three women not exposed to cadmium who served as the control group (C).
Plasma concentration, urinary excretion, renal clearance rates, net tubular reabsorption, and percentages of tubular reabsorption of 25 amino acids were obtained by short-term clearance studies.
The results indicated that:
1) The clearance of most individual amino acids were much higher in the Cd-exposed group than in the control group.
2) The percentages of tubular reabsorption of most amino acids were characteristically lower in the Cd-exposed group than in the control group.
3) Amino acid clearance patterns were similar for suspected itai-itai patients and women with renal damage from cadmium.