1984 Volume 39 Issue 3 Pages 662-669
The effect of a single dose of pentachlorophenol (PCP) was studied in fasted male Wistar rats. A marked depletion of hepatic glycogen and a significant increase of blood sugar were observed 3 hours following administration. In contrast, prolonged PCP treatment induced remarkable glycogen storage of more than 10 times the fasted control level.
The enzymatic studies suggested that the early depletion of hepatic glycogen was caused by a stimulation of phosphorylase activity, which, in turn, resulted in elevation of blood glucose. Hepatic glycogen storage due to PCP at a later stage could be attributable to the acceleration of glucose-6-phosphate-independent (I) form of liver glycogen synthetase.
Enhancement of adrenocortical activity observed in the early stage suggested that adrenocortical hormone plays a role in the initial fall of hepatic glycogen due to PCP.
