Abstract
Inhibitory action of some chemicals and antiserum on the enhanced lethal toxicity due to the combination of thermostable direct hemolysin produced by Vibrio parahaemolyticus and staphylococcal enterotoxin was investigated with animal experiments.
No inhibition was found with calcium chloride, epinephrin, dopamine, β-methasone and theophyllin administrated to rats either singly or by mixture.
However, the lethal toxicity was repressed with antiserum for the Vibrio thermostable direct hemolysin after injection of the toxins; one rat in six survived with treatment with 0.5mg/kg of the antiserum and three out of six were left alive with 1mg/kg administered treatment.
Furthermore, the effect of antiserum was increased by adding theophyllin and no rat died in the case treated with 1mg/kg of antiserum and 40mg/kg of theophyllin.
