Abstract
The purpose of this study is to make clear a comprehensive relationship between activity and fraction ratio of serum γ-GTP and serum vitamin C. Futhermore, the effects of large doses of vitamin C on activity and fraction ratio of serum γ-GTP were examined.
1) In an epidemiological study, no significant correlation was found between serum total γ-GTP activity and serum vitamin C in healthy young volunteers (178 men and 39 women excluding habitual users of alcohol).
However, high inverse correlations were found between fraction ratio of γ-GTP (1) and serum vitamin C in young men and women. For men, the correlation between fraction ratio of γ-GTP (1) and serum vitamin C conformed to Y=-0.06X+4.29 (N=178 r=-0.582 p<0.01), while that between fraction ratio of γ-GTP (1) and serum vitamin C conformed to Y=-0.06X+4.30 (N=39 r=-0.433 p<0.01) in women.
2) In a laboratory study, we administered vitamin C at a dose of 1g/day for 10 days and then at a dose of 10g/day for 10 days to six subjects, but found no significant difference between serum total γ-GTP activity before and after treatment. However, fraction ratio of γ-GTP (1) levels of all subjects tended to decrease during the administration of large doses of vitamin C.
