CHEMORADIOTHERAPY WITH MULTI DRUGS IN PATIENTS WITH LOCALLY ADVANCED SQUAMOUS CELL CARCINOMA OF THE HEAD AND NECK (SCCHN)

Abstract

This study evaluated the efficacy and toxicity of chemoradiotherapy (CRTx) using docetaxel (DOC), cisplatin (CDDP) and 5-fluorouracil (5-FU), (TPF) and CDDP, 5-FU, Methotexate (MTX) and Leucovorin (LV), (PFML) in patients with locally advanced squamous cell carcinoma of the head and neck (SCCHN). Patients received 2 cycles of chemotherapy. We compared it with neo-adjuvant chemotherapy (CTx) followed by radiation (RTx) and concurrent CRTx using TPF or PFML. Leukocytopenia, neutropenia and mucositis were severer in patients using concurrent CRTx than neo-adjuvant CTx followed by RTx. CR rate was better in patients using concurrent CRTx than neo-adjuvant CTx followed by RTx. The limit at which we expected CR in concurrent CRTx was ≤T3 and ≤N2b patients.