Abstract
We report the results of superselective intraarterial CDDP infusion therapy for 12 patients with locally advanced oropharyngeal carcinomas, compared with 47 patients treated before 1999. In the previously treated patients, 27 patients received surgery on the original site, and all of them had extensive operations combined with reconstruction surgery. The other 20 patients were mainly treated by conventional external beam irradiation. In the patients treated with intraarterial infusions, CDDP was administered at a dose of 100mg/m2 per one or two weeks in combination with irradiation.
The 5-year cause-specific survival rates in the past group were 33.3% for non-surgical patients of T3, 62.2% for surgery-received patients of T3, 25.4% for non-surgical patients of T4, and 48.6% for surgery-received patients of T4, but the 5-year overall survival rates were almost the same among the groups. On the other hand, the effect of intraarterial infusion therapy was remarkable. The CR and PR rates for the original site were 91.3% and 100%, respectively, and 11 patients, including two patients that received salvage operations, are surviving without residual tumor. We conclude that intraarterial CDDP infusion therapy was very effective for patients with advanced oropharyngeal carcinoma.
