Abstract
Reg IV (Regenerating gene type IV) is a member of the Reg gene family which is associated with tissue degeneration, and is known to be up-regulated in inflammatory bowel diseases, gastric and colorectal cancer. The relationship between Reg IV expression and metastatic prostate cancer with refractory of hormone therapy or usefulness of serum marker in early pancreatic ductal carcinoma is reported. In an immunohistochemical examination of Reg IV in 25 cases of adenoid cystic carcinoma of the salivary gland, Reg IV expression was closely associated with nodal metastasis and distant metastasis. These results suggested that Reg IV might be a useful marker for prediction of metastasis and prognosis in adenoid cystic carcinoma.
