Three cases of Langerhans cell histiocytosis of the jaws

Abstract

Langerhans cell histiocytosis (LCH) is an extremely rare disease. The etiology of LCH remains to be defined, and the treatment of LCH has not been confirmed. We report three cases of LCH of the jaws. Case 1: a 14-year-old boy. LCH was recognized in the right molar region of the mandible. He received 10 Gy of radiotherapy and has had no evidence of disease for 8 years. Case 2: a 45-year-old woman. LCH was recognized in the bilateral molar regions of the jaws. Curettage and resection were performed, but some lesions recurred. An immunosuppressive agent was administered, and she has had no evidence of disease for 5 years. Case 3: a 38-year-old woman. LCH was recognized in the left molar region to the ramus of the mandible. Seven months after removal of the lesion, the disease recurred and she received 30 Gy of external irradiation. She has had no evidence of disease for 5 months. Long-term follow-up is necessary considering local recurrence of the disease and transformation into multifocal disease.