耳下腺癌と顎下腺癌の比較：多施設共同による後方視的研究

山田 光一郎; 本多 啓吾; 田中 信三; 玉木 久信; 児嶋 剛; 篠原 尚吾; 竹林 慎治; 前谷 俊樹; 安里 亮; 楯谷 一郎; 北村 守正; 水田 匡信; 木谷 芳晴; 牛呂 幸司; 市丸 和之; 隈部 洋平; 大森 孝一

doi:10.5981/jjhnc.44.39

The comparison of parotid gland carcinoma and submandibular gland carcinoma―Results of a multi-institutional retrospective study

Koichiro Yamada, Keigo Honda, Shinzo Tanaka, Hisanobu Tamaki, Tsuyoshi Kojima, Shogo Shinohara, Shinji Takebayashi, Toshiki Maetani, Ryo Asato, Ichiro Tateya, Morimasa Kitamura, Masanobu Mizuta, Yoshiharu Kitani, Koji Ushiro, Kazuyuki Ichimaru, Yohei Kumabe, Koichi Omori

Author information

Koichiro Yamada
Department of Otolaryngology, Japanese Red Cross Wakayama Medical Center
Keigo Honda
Department of Otolaryngology, Japanese Red Cross Wakayama Medical Center
Shinzo Tanaka
Department of Otolaryngology-Head ＆ Neck Surgery, Japanese Red Cross Osaka Hospital
Hisanobu Tamaki
Department of Otolaryngology-Head ＆ Neck Surgery, Kurashiki Central Hospital
Tsuyoshi Kojima
Department of Otolaryngology, Tenri Hospital
Shogo Shinohara
Department of Otolaryngology-Head ＆ Neck Surgery, Kobe City Medical Center General Hospital
Shinji Takebayashi
Department of Otolaryngology-Head ＆ Neck Surgery, Kobe City Medical Center General Hospital
Toshiki Maetani
Department of Otolaryngology-Head and Neck Surgery, Medical Research Institute, Kitano Hospital
Ryo Asato
Department of Otolaryngology-Head ＆ Neck Surgery, National Hospital Organization Kyoto Medical Center
Ichiro Tateya
Department of Otolaryngology-Head ＆ Neck Surgery, Kyoto University Graduate School of Medicine
Morimasa Kitamura
Department of Otolaryngology-Head ＆ Neck Surgery, Kyoto University Graduate School of Medicine
Masanobu Mizuta
Department of Otolaryngology-Head ＆ Neck Surgery, Kyoto University Graduate School of Medicine
Yoshiharu Kitani
Department of Otorhinolaryngology-Head ＆ Neck surgery, Shizuoka General Hospital
Koji Ushiro
Department of Otolaryngology, Japanese Red Cross Otsu Hospital
Kazuyuki Ichimaru
Department of Otolaryngology-Head ＆ Neck Surgery, Kokura Memorial Hospital
Yohei Kumabe
Department of Otolaryngology-Head ＆ Neck Surgery, Hyogo Prefectural Amagasaki General Medical Center
Koichi Omori
Department of Otolaryngology-Head ＆ Neck Surgery, Kyoto University Graduate School of Medicine

Keywords: Parotid gland carcinoma, Submandibular gland carcinoma, Prognosis, Distant metastasis

JOURNAL FREE ACCESS

2018 Volume 44 Issue 1 Pages 39-45

DOI https://doi.org/10.5981/jjhnc.44.39

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Abstract

Objective: Parotid gland carcinoma （PGC） and submandibular gland carcinoma （SMGC） are relatively rare. The aim of this retrospective study was to compare the clinical outcomes of PGC and SMGC.
Patients: Our study included 260 patients （195 with PGC and 65 with SMGC） who underwent initial surgical treatment at Kyoto University and its affiliated hospitals between 2006 and 2015.
Results: A total of 44％ of the PGCs and 58％ of the SMGCs were classified as high-grade malignancies. The sensitivity of fine-needle aspiration cytology was 50％ for PGC and 75％ for SMGC. At a mean follow-up time of 3.6 years, the 3-year overall survival, disease-specific survival （DSS）, locoregional control, and no distant metastasis （NDM） rates for PGC were 85％, 89％, 85％, and 87％, respectively, while those for SMGC were 74％, 74％, 90％, and 65％, respectively. Furthermore, the DSS and NDM rates for SMGC were statistically significantly lower than those for PGC.
Conclusions: In comparison to PGC, SMGC has a higher risk of distant metastasis and a poorer DSS rate.

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