Abstract
We report a case of huge squamous cell carcinoma derived from cheek skin. A 57-year-old man visited our hospital because of a huge tumor on the right face. His right face, including his right eyeball, was replaced by a huge tumor. CT scan revealed that the tumor invaded his paranasal sinuses and skull base bone. We resected the tumor including facial skin, right eyeball and skull base bone. After resection, we reconstructed his face with two free flaps and two free bones.