Study on the treatment outcomes of advanced laryngeal and hypopharyngeal cancer with induction chemotherapy

Abstract

Induction chemotherapy （ICT） of DTX＋CDDP＋5-FU （TPF） has been reported to be useful as pretreatment preceding standard CDDP combination chemoradiotherapy （CCRT） for head and neck cancer. However, ICT causes many adverse events, and its effectiveness is still controversial. We conducted a study on ICT followed by CCRT in 30 cases of advanced laryngeal and hypopharyngeal cancer with a desire for laryngeal preservation. We examined completion rates, success rates based on primary tumor （T） and neck lymph node （N） metastasis, prognosis, and laryngeal preservation. Nine cases had laryngeal cancer （Stage Ⅲ：4 cases, Stage Ⅳ：5 cases） and 21 cases had hypopharyngeal cancer （Stage Ⅲ：3 cases, Stage Ⅳ：18 cases）. The completion rate of ICT （TPF 2 courses） was 93％, and the completion rate of ICT＋CCRT was 82％. The success rate of ICT was T100％, N80％, and the success rate of ICT＋CCRT was T97％, N92％. The two-year overall survival rate was 75％, and the two-year laryngeal preservation survival rate was 67％, indicating good results. From this study, it is considered that good completion and effects can be achieved with TPF-based ICT and CCRT by selecting cases and addressing adverse events.