Abstract
Two cases of malignant melanoma (MM), with primary lesions in the nasal cavity and vestibule of the nose were successfully treated with local injection of interferon (IFN). Both cases showed complete response (CR). One case, MM of the nasal cavity was not responsive to DAV therapy and Linac radiotherapy. In this case, local injection of IFN was only effective. And this case had a CR after about 18 months and the number of local injections of IFN-α were 249 and the total quantity was 74, 700×104 IU. The other case, primary lesion of the vestibule of the nose was treated only with local injection of IFN-β. This case had a CR after about 4.5 months and the number of local injections of IFN-β were 115 and the total quantity was 33, 880×104IU. Primary treatment of MM is a wide range excision of the tumor lesion and its surrounding normal tissue. However, when this is not possible due to the diffcult location of the tumor, local injection of IFN may be successfully used in some cases.
