Japanese jornal of Head and Neck Cancer
Online ISSN : 1883-9878
Print ISSN : 0911-4335
ISSN-L : 0911-4335
Nation-wide Study of Iethal Midline Granuloma in Japan
Katsuyuki AOZASAKeisuke HORIUCHIRyouji SASAKIHajime MAEDAToru MATSUNAGAI. FRIEDMANN
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JOURNAL FREE ACCESS

1990 Volume 16 Issue 2 Pages 69-72

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Abstract
Lethal midline granuloma (LMG) is clinical term, and it is histologically composed of Wegener's granulomatosis (WG), polymorphic reticulosis (PR), and malignant lymphoma (ML). WG is an inflammatory disease, and PR and ML are considered to represent a neoplastic proliferation of lymphoreticular cells. Recenti mmunohistochemical and molecular cytogenetic studies suggested a T-cell nature of the proliferating cells in PR. In the present report, a nation-wide study on LMG in Japan is compared with a study from UK, to examine differences in frequencies of each diseases in Eastern and Western countries. A total of 340 cases of LMG were examined. On the basis of histological and clinical findings, these cases were categorized as 68 WG, 129, PR, 92 ML, 44 chronic inflammation not specified, and 7 other related conditions.
The crude frequencies of WG, PR, and ML, per 100, 000 outpatients of ENT clinics in Japan and England were 4, 8, and 6, respectively, and 8, 4, 1, respectively. The predominance of malignant lymphoproliferative diseases to WG in Japan (3.5:1) was in marked contrast to the situation in the UK (1:1.6). Excess of PR among the cases with lymphoproliferative diseases in the Kyushu district compared to other districts in Japan was evident. A review of the pertinent literature suggests a clustering of malignant lymphoproliferative diseases of the nose among Mongolian ethnic groups.
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© Japan Society for Head and Neck Cancer
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